Current theories propose that anxiety adversely impacts working memory (WM) by restricting WM capacity and interfering with efficient filtering of task-irrelevant information. The current study investigated the effect of shock-induced state anxiety on WM capacity and the ability to filter task-irrelevant neutral stimuli. We measured the contralateral delay activity (CDA), an event-related potential that indexes […]
Category Archives: Publications
Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity
Introduction: Resting state functional magnetic resonance imaging (rsfMRI) studies demonstrate that individuals with posttraumatic stress disorder (PTSD) exhibit atypical functional connectivity (FC) between the amygdala, involved in the generation of emotion, and regions responsible for emotional appraisal (e.g., insula, orbitofrontal cortex [OFC]) and regulation (prefrontal cortex [PFC], anterior cingulate cortex). Consequently, atypical amygdala FC within an emotional processing and regulation network […]
rsFC of Skin Picking
Pathological skin picking (excoriation) is a relatively common disorder. Although it has been hypothesized to share a similar pathophysiological basis as other obsessive-compulsive (OC) spectrum disorders, to date, little work has specifically examined the precise neurobiological mechanisms involved in excoriation. Disruption in functional circuits involving the right inferior frontal gyrus (rIFG) and supplementary motor area (SMA) may be particularly […]
Image processing for ABCD
The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive […]
Amygdala functional connectivity following trauma
Understanding neural mechanisms that confer risk for posttraumatic stress disorder (PTSD) is critical for earlier intervention, yet longitudinal work has been sparse. The amygdala is part of a core network consistently implicated in PTSD symptomology. Most neural models of PTSD have focused on the amygdala’s interactions with the dorsal anterior cingulate cortex, ventromedial prefrontal cortex, […]
Extended amygdala and uncertainty
Relative to the centromedial amygdala (CM), the bed nucleus of the stria terminalis (BNST) may exhibit more sustained activation toward threat, sensitivity to unpredictability, and activation during anxious anticipation. These factors are often intertwined. For example, greater BNST (vs. CM) activation during a block of aversive stimuli may reflect either more sustained activation to the […]
High-resolution connectivity of the extended amygdala
The extended amygdala has been implicated as a critical region in the neurocircuitry underlying anxiety. The circuitry of the extended amygdala, including the central (CeA) and basolateral (BLA) nuclei of the amygdala and the bed nucleus of the stria terminalis (BNST), has been well-defined in non-human animals; however, much less is known about the roles […]
Reward distracters and working memory filtering
Reward‐related stimuli capture attention, even when they are task irrelevant. A consequence of attentional prioritization of reward‐related stimuli is that they may also have preferential access to working memory like other forms of emotional information. However, whether reward‐related distracters leak into working memory remains unknown. Here, using a well‐validated change detection task of visual working […]
A pilot randomized trial of a dual n-back emotional working memory training program for veterans with elevated PTSD symptoms.
Anxiety is characterized by excessive attention to threatening information, leading to impaired working memory (WM) performance and elevated anxious thoughts. Preliminary research indicates that individuals with PTSD show particular difficulty with WM in emotional contexts (Schweizer et al., 2011). Although several studies show that computerized training can improve WM capacity for anxious individuals (Owens et […]
State Anxiety Impairs Proactive but Enhances Reactive Control
Cognitive control is a construct that prioritizes how we process stimuli and information to flexibly and efficiently adapt to internal goals and external environmental changes. The Dual Mechanism of Control (DMC) theory delineates two distinct cognitive control operations: proactive control and reactive control (Braver, 2012). Anxiety has been posited to differentially affect proactive and reactive […]