State Anxiety Impairs Proactive but Enhances Reactive Control

Cognitive control is a construct that prioritizes how we process stimuli and information to flexibly and efficiently adapt to internal goals and external environmental changes. The Dual Mechanism of Control (DMC) theory delineates two distinct cognitive control operations: proactive control and reactive control (Braver, 2012). Anxiety has been posited to differentially affect proactive and reactive […]

Structural connectivity of the posterior cingulum is related to re-experiencing symptoms in PTSD.

Posttraumatic stress disorder (PTSD) is a heterogeneous disorder with disturbances in hyper-arousal or avoidance behaviors, and intrusive or re-experiencing thoughts. The uncinate fasciculus (UF) and cingulum bundle are white matter pathways implicated in stress and trauma pathophysiology, yet their structural integrity related to PTSD symptom domains is yet to be understood. Forty-four trauma-exposed young adults […]

Moderating effects of harm avoidance on resting-state functional connectivity of the anterior insula.

Background: As an index of behavioral inhibition and an individual’s propensity to avoid, rather than seek, potentially dangerous situations, harm avoidance has been linked to internalizing psychopathology. Altered connectivity within intrinsic functional neural networks (i.e., default mode [DMN], central executive [CEN], and salience networks [SN]) has been related to internalizing psychopathology; however, less is known […]

Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety

Fear extinction is a powerful model of adaptive and anxiety-related maladaptive fear inhibition. This learning process is dependent upon plastic interactions between the amygdala, anterior midcingulate cortex (aMCC), hippocampus, and the ventromedial prefrontal cortex (vmPFC). With regard to the amygdala, the basolateral (BLA) and centromedial amygdala (CMA) serve unique roles in fear extinction. In a […]

Abnormal cortical gyrification in criminal psychopathy.

Background: Psychopathy is a personality disorder characterized by interpersonal and emotional abnormalities (e.g., lack of empathy and guilt) and antisocial behavior. Psychopathy has been associated with a number of structural brain abnormalities, most notably in orbital frontal and anterior/medial temporal regions, that may underlie psychopathic individuals’ problematic behaviors. Past research evaluating cortical structure in psychopathy […]